The number one concern in dosing these medications is the levothyroxine as it has the narrowest therapeutic index and can be the easiest medication to affect by changing/adding other medications. If your thyroid medication isnât working well, there could be a couple reasons why. This can â¦ Some of the Synthroid-drug interactions can result in significant changes for the other drugs. Do not take levothyroxine and go back to your doctor to discuss your treatment if you have: had an allergic reaction to levothyroxine or any other medicines in the past; an overactive thyroid (hyperthyroidism) Can I take T3 in the morning and continue taking T4 at night? Based on the information above, it sounds like it may be better to take T3 medication in the morning. By contrast, Synthroid can make other drugs more effective. The drug levothyroxine (Synthroid, Levoxyl, others) has long been the treatment for sluggish thyroids or hypothyroidism. I am in the process of adding a T3 to my regime, as well as switching from Synthroid to Tirosint. Synthroid can make some drugs less effective, so you will need to increase the dose of these drugs. Trying to take my thyroid medicine on an empty stomach and wait an hour before eating or drinking was really inconvenient. Here, weâll talk about why these things can affect your thyroid medication, and how you can prevent any issues. (NOTE: I no longer take levothyroxine, but am on two other thyroid medications; they do not need to be taken with coffee either. Taking the right supplements can help you fight food cravings, fill in dietary gaps, support brain health, gut health, bone health, metabolic function, and so much more. However, levothyroxine is not suitable for some people. Find out if you can take non-prescription medicines with levothyroxine and what medicines could affect your thyroid treatment By Helen Marshall, BPharm, MRPharmS 01/04/2019 Levothyroxine can be taken by adults and children. However, some supplements can react with thyroid medications, leaving you with the frustration of coping with a variety of unsavory, even detrimental complications. Both bottles say what the above says, except one says to take it on an empty stomach 30-60 minutes before breakfast.) That was unfortunately short lived. Levothyroxine oral tablet can interact with other medications, vitamins, or herbs you may be taking.An interaction is when a substance changes the way a drug works. They include diabetes medications (pills and insulin), theophylline, and digoxin. Unfortunately, the bioavailability of levothyroxine can be reduced by a variety of other medications, leading to reduced levothyroxine effect. I could barely drag myself out of bed. Possible explanations include switching between different thyroid medications, experiencing a sudden change in weight, or taking your medication with food, vitamin supplements, or coffee. One would expect that thyroid hormones other than levothyroxine would interact similarly with the drugs described in this article. But that can make the regimen inconvenient for some, and compliance declines. Levothyroxine is widely used to treat patients with thyroid disorders. Other readers have found it helpful to switch to taking Synthroid at bedtime. The pill needs time to be absorbed properly, so patients are often instructed to take it daily a half hour to an hour before breakfast. If you are already taking your other medications (e.g. One person wrote: âIâve been taking levothyroxine for years and have felt crappy the whole time.