I was an oily, depressed mess. I will typically combine spironolactone with an oral contraceptive to reduce breakthrough bleeding, and I'll add topical therapy for a faster response. If only using spironolactone, then you should see some improvement by 2 months, and ideally wait 3-4 months for more optimal results. However, acne may return after you stop taking spironolactone. My skin before was ridiculous. ... Month six on 200 mg spironolactone, still some pink scarring, but I could not be happier with the results. I still got some pimples, but they would only be minor whiteheads usually rather than painful cystic acne. I did not have an initial breakout. And my 34DD chest went to a DDD and I had to wear sports bras lol but im ok with that. And lo and behold, my acne cleared 3 months later. I think it helped to control my oily skin and cystic acne. Is this just an initial breakout and then things get better? Patients received treatment with spironolactone for a median duration of 7 months (range, 3‐45 months) with limited side effects. Spironolactone may be taken for several years, but because … Spironolactone is a diuretic medication. Basically, Spironolactone blocks androgen receptors and reduces the production of oil in the sebaceous glands, according to him. If you get side effects within that initial trial timeframe, then I would either consider counter measures like drinking more water or drinking/eating more foods with electrolytes, or, if the side effects are too much, discontinue the medication altogether. Dr. Benjamin Barankin, Toronto Dermatology Centre. Find out how spironolactone improves the appearance of hormonal acne, side effects, and more. Conclusions. 4ish cysts on both sides of my face at once and the monthly in-between eyebrow breakouts. Spironolactone demonstrated efficacy in treating acne in adolescent females and is a safe long‐term alternative to systemic antibiotics in these patients. It’s like dandelion tea, but in pill form! The author had been treating her chronic moderate-to-severe acne for 15 years, with little luck. 256. L-Lysine ABSOLUTELY treats acne. “With hormonal acne, … Im a 27 year old … I am writing this post because I have been consistently confused over the years that there seems to be so little mention of L-Lysine as an acne treatment both on acne.org and elsewhere on the internet. Spironolactone is an acne treatment prescribed by dermatologists. I have been on Spiro for 3 months today. Spironolactone is a powerful medication that may help reduce moderate or severe hormonal acne breakouts. Scientifically speaking, spironolactone is a diuretic that helps your kidneys expel water and salt. 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