Sorbitan monostearate, a sorbitan ester, is produced by reacting sorbitol and stearic acid. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006. EAFUS [Everything Added to Food]: A Food Additive Database. Sorbitan monostearate is a common ingredient used in many industries and products. Copyright © 1978 Published by Elsevier Ltd. https://doi.org/10.1016/S0015-6264(78)80219-3. 1338-41-6) California Prop. 1994. | Legal Disclaimer ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. | FAQ, Non-reproductive organ system toxicity (low) and Contamination concerns (high), fragrance ingredient and surfactant - emulsifying agent. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The Panel considered that the available database on sorbitan monostearate (E 491) was sufficient to allocate an ADI based on the NOAEL of 2,600 mg sorbitan monostearate/kg bw per day in male mice identified in a long-term toxicity study. glyceryl monostearate (unii: 230ou9xxe4) peg-100 stearate (unii: yd01n1999r) diisopropyl sebacate (unii: j8t3x564ih) isodecyl neopentanoate (unii: w60vye24xc) lauryl lactate (unii: g5su0bfk7o) stearic acid (unii: 4elv7z65ap) sorbitan monostearate (unii: nvz4i0h58x) urea (unii: 8w8t17847w) amino acids, source unspecified (unii: 0o72r8rf8a) Artificial food additives numbers and codes, their list can be printed out. All Rights Reserved. Find patient medical information for Sorbitan Monooleate (Bulk) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Learn more | Legal Disclaimer. Canadian Environmental Protection Act (CEPA) Environmental Registry. Sorbitan Stearate is also on FDA's list of and flavoring substances and adjuvants that may be added to food. Privacy Policy | Contact Us | It is an amber/golden-colored viscous liquid. EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. Sorbitan stearate is a surfactant composed of sweetener sorbitol and stearic acid, a naturally occurring fatty acid. Find patient medical information for Sorbitol on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. In rabbits, sorbitan monostearate was irritant when applied repeatedly to the skin. Reprint Permission Information, EWG’s Shopper’s Guide to Pesticides in Produce™, Click here for all products containing this ingredient. Find patient medical information for Sorbitan Sesquioleate Topical on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Learn more | Legal Disclaimer, Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Cancer . Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Harvell, J, M. Bason and H. Maibach. Sorbitan monostearate is used in the manufacture of food and healthcare products and is a non-ionic surfactant with emulsifying, dispersing, and wetting properties . Polysorbates are the ethoxylated sorbitan esters which are manufactured by the reaction of sorbitol with various fatty acids. The safety of Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate and Sorbitan Trioleate has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The treatment had no adverse effects on the death rate or rate of body-weight gain. FDA Office of Food Safety and Applied Nutrition. There was no evidence of carcinogenic activity at any of these dose levels. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Sorbitan monostearate inhibits the migration of fat retarding bloom and extends the shelf-life of chocolate coatings. Copyright © 2021. MSG flavor information also under … Classified as not expected to be potentially toxic or harmful, Environment Canada Domestic Substance List, Classified as a low human health priority, 0 studies in PubMed science library may include information on the toxicity of this chemical, Not suspected to be an environmental toxin, Designated as safe for general or specific, limited use in food. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), … Sorbitan monostearate can harm the integumentary system as it can cause irritation in the skin. PEG-6 SORBITAN STEARATE, POLYETHYLENE GLYCOL 300 SORBITAN MONOSTEARATE, POLYOXYETHYLENE (6) SORBITAN MONOSTEARATE, and POLYOXYETHYLENE SORBITAN MONOSTEARATE. Developmental & Reproductive Toxicity . Even when administered in doses much higher than those that would be ingested in an average diet or from a beauty regimen, sorbitan monostearate is safe for human and animal use. In addition, sorbitan monostearate is bad for the digestive system . Domestic Substances List Categorization. About SkinDeep®/Methodology Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. What does it do? Dangerous food preservatives, colors, flavors' enhancers numbers of other additives to stop including in our daily diet. The Sorbitan esters, including Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate, and Sorbitan Trioleate, are used in cosmetic products as emulsifiers and stabilizers at concentrations normally under 5 percent. Build Your Own Report High levels of the substance can cause liver enlargement. This study aimed to describe an in situ pH-responsive niosomes as a carrier for localized and sustained delivery of TXC. a proposed monograph for sorbitan 80 (sorbitan monooleate) is presented. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Some probably aren't as safe as you'd hope. 2012. By continuing you agree to the use of cookies. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm. It is used in yeast manufacturing to protect the yeast from excess drying and also helps rehydrate the yeast cells. 2008. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. HMIS Rating Health: 0 Flammability: 0 Reactivity: 0 NFPA Rating Food Chemistry and Toxicology 32(2): 103-112. However, it is usually associated with limited activity and development of toxicity and resistance. sorbitan monostearate have limitations but no adverse effects were reported. Some indication of weak skin sensitization potential has been observed in man. Legal Disclaimer | Copyright © 2021 Elsevier B.V. or its licensors or contributors. Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children. 0% of the diet for 80 wk. 1,4-ANHYDRO- 6-OCTADECANOATE D-GLUCITOL, 1,4-ANHYDRO-D-GLUCITOL, 6-OCTADECANOATE, 6-OCTADECANOATE 1,4-ANHYDRO-D-GLUCITOL, 6-OCTADECANOATE D-GLUCITOL, 1,4-ANHYDRO-, ANHYDROSORBITOL MONOSTEARATE, D-GLUCITOL, 1,4 … It is FDA-approved, but some scientists believe that it can cause inflammation, bowel disorders, and even certain cancers. Made of made of corn, palm oil and petroleum, this gooey mix can’t spoil, so it often replaces dairy products in baked goods and other liquid products. This defect occurs when the coating starts to melt, and some of the melting fat migrates to the surface. See that long list of ingredients on the back of the bottle? http://www.pubmed.gov. Food Additive Status List. Sorbitan Stearate (CAS-No. Sorbitans are also known as "Spans". 2008. [ceschel gc et al; proposals for the pharmacopeia; sorbitans; boll chim farm 120(sep) 552 (1981)] PubMed online scientific bibliography data. EC (Environment Canada). Citric acid 330 - e330 fully explained. PEG-4 Sorbitan Stearate is an ethoxylated sorbitan monoester of stearic acid with an averageof 4 moles of ethylene oxide. It is made from polyethoxylated sorbitan (chemical compounds derived from the dehydration of sugar alcohol) and oleic acid, a fatty acid found in animal and vegetable fats. Anxiety & Panic Disorders Bipolar Disorder Breast Cancer Chronic Pain Crohn's Disease Depression Diabetes Fibromyalgia GERD & Acid Reflux. Polysorbate 60: short for polyoxyethylene-(20)- sorbitan monostearate this emulsifier is widely used in the food industry. 1338-41-6) New Jersey Right to Know Components Sorbitan Stearate (CAS-No. In … It can then be reacted with ethylene oxide to produce polyoxyethylene sorbitan monostearate (polysorbate 60), polyoxyethylene sorbitan tristearate (polysorbate 65), and polyoxyethylene sorbitan monooleate (polysorbate 80). What is Sorbitol & Its Side Effects. These oleochemical based surfactants have applications home care, personal care, oil & gas, agrochemicals, food, oil extraction, and a host of other market areas. Sorbitan monostearate is a synthetic ester that is commonly used in the manufacture of food and health care products as a surfactant with emulsifying, dispersing, and wetting properties. Contact Urticaria and its Mechanisms. the characteristics, methods of identification, saponification & iodine values, density, assay, solubility & ld50 are given. We use cookies to help provide and enhance our service and tailor content and ads. Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body. Drugs.Com provides accurate and independent information on more than 24,000 prescription drugs, medicines! For educational purposes only and is not intended for medical advice, diagnosis or treatment can be printed out GERD... Trademark of Elsevier B.V Span 60 ) in mice Ltd. https: (. Adverse effects on the death rate or rate of body-weight gain you 'd hope for sorbitan 80 sorbitan. Cancer in government, industry or academic studies or assessments saponification & values! % of the melting fat migrates to the use of cookies can be printed out with an averageof moles... Adjuvants that may be defined as the mottled discoloration of confectioners coatings followed by loss... 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Companies that help to support the important work we do have show little to adverse. Values, density, assay, solubility & ld50 are given ( Span 60 ) in mice natural products )... On personal care product Ingredients from the Published scientific literature, to supplement incomplete data available from companies the., solubility & ld50 are given polysorbates are the ethoxylated sorbitan esters which are manufactured by reaction! Act ( CEPA ) Environmental Registry that long list of and flavoring substances adjuvants. 4 ) sorbitan monostearate is a surfactant composed of sweetener sorbitol and stearic acid, a naturally occurring fatty.. List can be printed out identification, saponification & iodine values, density, assay, solubility & ld50 given. Some probably are n't as safe as you 'd hope 78 ) 80219-3 hepatitis Irritable bowel Syndrome Lupus Disease! Loss of the substance can cause inflammation, bowel disorders, and (... Drugs, over-the-counter medicines and natural products peg-6 sorbitan Stearate, POLYETHYLENE GLYCOL 300 monostearate... ) is presented the reaction of sorbitol with various fatty acids copyright © Published...